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Mammalian variations on a theme: a Smo and Sufu surprise DEVELOPMENTAL CELL Oro, A. E. 2006; 10 (2): 156-158

Abstract

Hedgehog signaling plays a critical role during development and tumorigenesis. While much mechanistic insight has come from pathway investigations in the fruit fly, recent studies suggest a distinct mammalian strategy for signaling from Smoothened to Gli through the novel protein Suppressor of Fused that may have therapeutic implications.

View details for DOI 10.1016/j.devcel.2006.01.006

View details for Web of Science ID 000235480500004

View details for PubMedID 16459294