Hedgehog signaling plays a critical role during development and tumorigenesis. While much mechanistic insight has come from pathway investigations in the fruit fly, recent studies suggest a distinct mammalian strategy for signaling from Smoothened to Gli through the novel protein Suppressor of Fused that may have therapeutic implications.
View details for DOI 10.1016/j.devcel.2006.01.006
View details for Web of Science ID 000235480500004
View details for PubMedID 16459294