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Association of perioperative transfusion with survival and recurrence after resection of gallbladder cancer: A 10-institution study from the US Extrahepatic Biliary Malignancy Consortium

Association of perioperative transfusion with survival and recurrence after resection of gallbladder cancer: A 10-institution study from the US Extrahepatic Biliary Malignancy Consortium JOURNAL OF SURGICAL ONCOLOGY Lopez-Aguiar, A. G., Ethun, C. G., McInnis, M. R., Pawlik, T. M., Poultsides, G., Thuy Tran, Idrees, K., Isom, C. A., Fields, R. C., Krasnick, B. A., Weber, S. M., Salem, A., Martin, R. G., Scoggins, C. R., Shen, P., Mogal, H. D., Schmidt, C., Beal, E. W., Hatzaras, I., Shenoy, R., Cardona, K., Maithel, S. K. 2018; 117 (8): 1638–47

Abstract

Perioperative blood transfusion is associated with poor outcomes in several malignancies. Its effect in gallbladder cancer (GBC) is unknown.All patients with GBC who underwent curative-intent resection at 10-institutions from 2000 to 2015 were included. The effect of blood transfusion on overall survival (OS) and recurrence-free (RFS) was evaluated.Of 262 patients with curative-intent resection for GBC, 61 patients (23%) received blood transfusions. Radical cholecystectomy was the most common procedure (80%), but major hepatectomy was more frequent in the transfusion versus no-transfusion group (13% vs 4%; P?=?0.02). The transfusion group was less likely to have incidentally discovered disease (57% vs 74%) and receive adjuvant therapy (29% vs 48%), but more likely to have preoperative jaundice (23% vs 11%), T3/T4 tumors (60% vs 39%), LVI (71% vs 40%), PNI (71% vs 48%), and major complications (39% vs 12%) (all P?

View details for PubMedID 29761515