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Liquid biopsy for infectious diseases: sequencing of cell-free plasma to detect pathogen DNA in patients with invasive fungal disease DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE Hong, D. K., Blauwkamp, T. A., Kertesz, M., Bercovici, S., Truong, C., Banaei, N. 2018; 92 (3): 210–13

Abstract

Diagnosis of life-threatening deep-seated infections currently requires invasive sampling of the infected tissue to provide a microbiologic diagnosis. These procedures can lead to high morbidity in patients and add to healthcare costs. Here we describe a novel next-generation sequencing assay that was used to detect pathogen-derived cell-free DNA in peripheral blood of patients with biopsy-proven invasive fungal infections. The noninvasive nature of this approach could provide rapid, actionable treatment information for invasive fungal infections when a biopsy is not possible.

View details for PubMedID 30017314