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Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis. Journal of neurovirology Valencia-Sanchez, C., Steenerson, K. K., Kelemen, K., Orenstein, R., Kusne, S., Grill, M. F. 2019

Abstract

Post-transplantation lymphoproliferative disorder (PTLD) is a complication of solid organ and hematopoietic stem cell transplantation. Cases with isolated central nervous system (CNS) disease are rare. Epstein-Barr virus (EBV) plays a causative role. We present a patient with EBV cerebellitis documented 5months prior to development of primary CNS PTLD (PCNS-PTLD). This case report demonstrates progression from EBV CNS infection to lymphoproliferative disorder, highlighting the importance of serial clinical and imaging monitoring in transplant patients post-EBV CNS infection. PCNS-PTLD should always be considered in the differential diagnosis for transplant patients presenting with CNS symptoms, even in cases with no evidence of EBV viremia. Earlier diagnosis and appropriate treatment could result in improved outcomes.

View details for DOI 10.1007/s13365-018-0711-8

View details for PubMedID 30607891