An MRI study of minor physical anomalies in autism JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS Hardan, A. Y., Keshavan, M. S., Sreedhar, S., Vemulapalli, M., Minshew, N. J. 2006; 36 (5): 607-611


The objective of this investigation was to examine the existence of minor physical anomalies (MPA) in autism. The interorbital and interlens distances were measured on MRI scans obtained from a sample of 40 non-mentally retarded individuals with autism and 41 healthy controls. No differences were observed between the two groups on any measurements. However, when the analysis was conducted using a split median procedure, individuals with autism and either low FSIQ, PIQ, or VIQ had shorter interorbital distances when compared to controls. Hypotelorism is a MPA that may be present in a subgroup of individuals with autism. Additional research is warranted using large sample sizes with a wide range of intellectual functioning.

View details for DOI 10.1007/s10803-006-0103-4

View details for Web of Science ID 000239927900004

View details for PubMedID 16609827