No Matter How You Splice It, RBM39 Inhibition Targets Spliceosome Mutant AML. Cancer cell Thomas, R., Majeti, R. 2019; 35 (3): 337–39


A report in this issue of Cancer Cell identifies the RNA-binding protein RBM39 as a potential target in spliceosome mutant AML that can be targeted by existing sulfonamide drugs. These results support a proposed clinical trial in patients with myeloid malignancies bearing spliceosome mutations relapsed or refractory to standard therapy.

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