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CONSTRUCTION AND CHARACTERIZATION OF AN ISOGENIC UREASE-NEGATIVE MUTANT OF HELICOBACTER-MUSTELAE INFECTION AND IMMUNITY SOLNICK, J. V., JOSENHANS, C., SUERBAUM, S., TOMPKINS, L. S., LABIGNE, A. 1995; 63 (9): 3718–21

Abstract

Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.

View details for Web of Science ID A1995RQ79200072

View details for PubMedID 7642313

View details for PubMedCentralID PMC173517