The role of necroptosis in atherosclerotic disease. JACC. Basic to translational science Leeper, N. J. 2016; 1 (6): 548–50


It is now known that cells don't always die by apoptosis, but can also undergo a process known as programmed cell necrosis, or necroptosis. In a study recently published in Science Advances, investigators reported that this pro-inflammatory process is active in human atherosclerosis, may promote growth of the necrotic core, and may serve as a novel molecular imaging and translational therapeutic target. These findings represent a major step in our goal to reduce coronary disease and stroke.

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