Specific cytokine and chemokine increases precede the appearance of anti-cyclic citrullinated protein (Anti-CCP) antibodies and rheumatoid factor (RF) in the pre-clinical period of rheumatoid arthritis (RA) development. Deane, K. D., Hueber, W., Majka, D. S., Tomooka, B. H., Gilliland, W. R., Parrish, L. A., Parish, M. C., Norris, J. M., Robinson, W. H., Holers, V. WILEY-LISS. 2006: S508

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