Skip to main content
 
Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

See our updated masking policy »

Stanford Health Care

Cerebrospinal fluid biomarkers for Alzheimer's and vascular disease vary by age, gender, and APOE genotype in cognitively normal adults. Alzheimer's research & therapy Li, G., Shofer, J. B., Petrie, E. C., Yu, C. E., Wilkinson, C. W., Figlewicz, D. P., Shutes-David, A., Zhang, J., Montine, T. J., Raskind, M. A., Quinn, J. F., Galasko, D. R., Peskind, E. R. 2017; 9 (1): 48

Abstract

This study sought to evaluate gender and APOE genotype-related differences in the concentrations of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) and cerebrovascular injury across the life span of cognitively normal adults.CSF amyloid beta1-42 (Aß42), phospho-tau-181 (p-tau181), and total tau were measured in 331 participants who were between the ages of 21 and 100. CSF E-selectin and vascular cell adhesion protein 1 (VCAM1) were measured in 249 participants who were between the ages of 50 and 100.CSF total tau and p-tau181 increased with age over the adult life span (p?

View details for DOI 10.1186/s13195-017-0271-9

View details for PubMedID 28673336

View details for PubMedCentralID PMC5496132