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Defining Long-Term Survivors Following Resection of Intrahepatic Cholangiocarcinoma. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Bagante, F. n., Spolverato, G. n., Weiss, M. n., Alexandrescu, S. n., Marques, H. P., Aldrighetti, L. n., Maithel, S. K., Pulitano, C. n., Bauer, T. W., Shen, F. n., Poultsides, G. A., Soubrane, O. n., Martel, G. n., Groot Koerkamp, B. n., Guglielmi, A. n., Itaru, E. n., Pawlik, T. M. 2017; 21 (11): 1888–97

Abstract

Intrahepatic cholangiocarcinoma (ICC) is an aggressive primary tumor of the liver. While surgery remains the cornerstone of therapy, long-term survival following curative-intent resection is generally poor. The aim of the current study was to define the incidence of actual long-term survivors, as well as identify clinicopathological factors associated with long-term survival.Patients who underwent a curative-intent liver resection for ICC between 1990 and 2015 were identified using a multi-institutional database. Overall, 679 patients were alive with =?5 years of follow-up or had died during follow-up. Prognostic factors among patients who were long-term survivors (LT) (overall survival (OS) =?5) were compared with patients who were not non-long-term survivors (non-LT) (OS ?5 cm (OR 2.40, 95% CI, 1.54-3.74, p < 0.001), and direct invasion of an adjacent organ (OR 3.98, 95% CI, 1.18-13.4, p = 0.026). However, a subset of patients (

View details for PubMedID 28840497