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Case Studies in Neuroscience: The electrophysiology of a human obsession in nucleus accumbens.

Case Studies in Neuroscience: The electrophysiology of a human obsession in nucleus accumbens. Journal of neurophysiology Miller, K. J., Prieto, T., Williams, N. R., Halpern, C. H. 2019

Abstract

Microelectrode recordings were performed during awake deep brain stimulation surgery for obsessive-compulsive disorder, revealing robust brain oscillations that were plainly visible throughout the ventral striatum. There was an elegant topological correspondence between each oscillation and the underlying brain anatomy, most prominently a ~35Hz gamma-oscillation specific to the nucleus accumbens. Direct provocation of the patient's contamination obsession modulated both firing rate and gamma-oscillation amplitude within the nucleus accumbens.

View details for DOI 10.1152/jn.00096.2019

View details for PubMedID 31017846