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Genomic-scale gene expression profiling of normal and malignant immune cells

Genomic-scale gene expression profiling of normal and malignant immune cells CURRENT OPINION IN IMMUNOLOGY Alizadeh, A. A., Staudt, L. M. 2000; 12 (2): 219-225

Abstract

Gene expression variation is critical for the normal development and physiology of immune cells. Using cDNA microarrays, a systematic, genomic-scale view of gene expression in immune cells at many stages of differentiation and activation can be obtained. From the high vantagepoint provided by this technology, the gene expression physiology of immune cells appears remarkably ordered and logical. Each stage of lymphocyte differentiation can be defined by a characteristic gene expression signature. Genes that are co-regulated over hundreds of experimental conditions often encode functionally related proteins. Gene expression profiles also provide unprecedented ability to define the molecular and functional relationships between normal and malignant lymphocyte cell populations.

View details for Web of Science ID 000085786300016

View details for PubMedID 10712950