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Targeting XBP-1 as a novel anti-cancer strategy CANCER BIOLOGY & THERAPY Koong, A. C., Chauhan, V., Romero-Ramirez, L. 2006; 5 (7): 756-759

Abstract

The survival and growth of tumor cells within the microenvironment of a solid tumor necessitates the adaptation of these cells to ER stress. Hypoxia, in the context of the tumor microenvironment, is a critical ER stress that activates the unfolded protein response (UPR). This review focuses on the role of the IRE1-XBP1 branch of the UPR and its role in mediating cell survival and tumor growth. Inhibition of this pathway will be discussed as a therapeutic strategy.

View details for Web of Science ID 000240705300017

View details for PubMedID 16861911