Volumetric alterations of the orbitofrontal cortex in autism PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY GirgiS, R. R., Minshew, N. J., Melhern, N. M., Nutche, J. J., Keshavan, M. S., Hardan, A. Y. 2007; 31 (1): 41-45


Recent evidence has implicated the orbitofrontal cortex (OFC) in the pathophysiology of social deficits in autism. An MRI-based morphometric study of the OFC was conducted involving 11 children with autism (age range 8.1-12.7 years) and 18 healthy, age-matched controls (age range 8.9-12.8 years). Decreased grey matter volume in the right lateral OFC in the patient group was found, and correlations were observed between social deficits and white, but not grey, matter structures of the OFC. These findings support the role of OFC in autism and warrant further investigations of this structure using structural and functional methodologies.

View details for DOI 10.1016/j.pnpbp.2006.06.007

View details for Web of Science ID 000243738000005

View details for PubMedID 16863674

View details for PubMedCentralID PMC2888006