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Radiation-induced effects on gene expression: An in vivo study on breast cancer 3rd International Conference on Translational Research and Pre-Clinical Strategies in Radiation Oncology Helland, A., Johnsen, H., Froyland, C., Landmark, H. B., Saetersdal, A. B., Holmen, M. M., Gjertsen, T., Nesland, J. M., Ottestad, W., Jeffrey, S. S., Ottestad, L. O., Rodningen, O. K., Sherlock, G., Borresen-Dale, A. ELSEVIER IRELAND LTD. 2006: 230–35

Abstract

Breast cancer is diagnosed worldwide in approximately one million women annually and radiation therapy is an integral part of treatment. The purpose of this study was to investigate the molecular basis underlying response to radiotherapy in breast cancer tissue.Tumour biopsies were sampled before radiation and after 10 treatments (of 2 Gray (Gy) each) from 19 patients with breast cancer receiving radiation therapy. Gene expression microarray analyses were performed to identify in vivo radiation-responsive genes in tumours from patients diagnosed with breast cancer. The mutation status of the TP53 gene was determined by using direct sequencing.Several genes involved in cell cycle regulation and DNA repair were found to be significantly induced by radiation treatment. Mutations were found in the TP53 gene in 39% of the tumours and the gene expression profiles observed seemed to be influenced by the TP53 mutation status.

View details for DOI 10.1016/j.radonc.2006.07.007

View details for Web of Science ID 000240882300018

View details for PubMedID 16890317