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DETERMINATION OF A UNIQUE AND IMMUNODOMINANT EPITOPE OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I JOURNAL OF INFECTIOUS DISEASES LIPKA, J. J., Bui, K., Reyes, G. R., Moeckli, R., Wiktor, S. Z., Blattner, W. A., Murphy, E. L., Shaw, G. M., Hanson, C. V., Sninsky, J. J., Foung, S. K. 1990; 162 (2): 353-357

Abstract

The identification and isolation of unique and immunogenic recombinant epitopes for human T cell lymphotrophic virus (HTLV) type I might allow the development of an antibody-based assay to differentiate between HTLV-I and HTLV-II infections. To test the feasibility of this approach, an HTLV-I envelope epitope was isolated by immunoscreening of a lambda gt11 recombinant HTLV-I DNA library with a human monoclonal antibody to HTLV-I. This recombinant epitope. MTA-4, when tested with sera from HTLV-I- or HTLV-II-infected individuals, was reactive with all HTLV-I and nonreactive with all HTLV-II antisera. These results indicate that MTA-4 is a unique and immunodominant epitope on HTLV-I and confirm the usefulness of human-derived monoclonal antibodies in an experimental approach to dissect the human humoral response to a viral pathogen.

View details for Web of Science ID A1990DQ92600009

View details for PubMedID 1695653