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LYMPHOTOXIN AND TUMOR NECROSIS FACTOR-ALPHA PRODUCTION BY MYELIN BASIC PROTEIN-SPECIFIC T-CELL CLONES CORRELATES WITH ENCEPHALITOGENICITY INTERNATIONAL IMMUNOLOGY Powell, M. B., Mitchell, D., Lederman, J., Buckmeier, J., Zamvil, S. S., Graham, M., Ruddle, N. H., Steinman, L. 1990; 2 (6): 539-544

Abstract

Lymphokine activity in seven myelin basic protein (MBP)-specific T cell clones was examined. All of the clones recognize MBP peptide 1-9 in the context of I-Au. A strong positive correlation was found between levels of lymphotoxin (LT) and tumor necrosis factor alpha (TNF-alpha) mRNA and biological activity on L929 cells and their capacity to induce paralysis, the clinical hallmark of experimental allergic encephalomyelitis (EAE). No correlation was found between interleukin-2 or gamma interferon production and encephalitogenicity. LT and/or TNF-alpha may play a central role in the pathogenesis of EAE.

View details for Web of Science ID A1990DK90100009

View details for PubMedID 1707660