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A SIMPLE, SINGLE, TRIAL-LEARNING PARADIGM FOR CONDITIONED INCREASE IN NATURAL-KILLER-CELL ACTIVITY

A SIMPLE, SINGLE, TRIAL-LEARNING PARADIGM FOR CONDITIONED INCREASE IN NATURAL-KILLER-CELL ACTIVITY PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE Solvason, H. B., Ghanta, V. K., Soong, S. J., Rogers, C. F., Hsueh, C. M., Hiramoto, N. S., Hiramoto, R. N. 1992; 199 (2): 199-203

Abstract

A change in natural killer (NK) cell activity can be conditioned with one trial learning when conditioned stimulus (CS) precedes the unconditioned stimulus (US). To avoid the problems associated with two reexposures in our earlier studies, we have developed a reliable and simple conditioning protocol utilizing the one trial learning and one reexposure to the odor CS. The conditioned change in NK cell activity was significantly different (P less than 0.05) from the control groups of mice. The paradigm is short and simple in that the conditioned change could be demonstrated within 3 days. We have also compared the effects of temporal association of CS and US on conditioned increase in NK cell activity. Forward conditioning (CS preceded the US) demonstrated a conditioned change, but the backward conditioning protocol did not. The paradigm provides a reliable approach to the study of mechanisms of the phenomenon of odor-NK conditioning.

View details for Web of Science ID A1992HA55800009

View details for PubMedID 1741412