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Genornics and the evolution, pathogenesis, and diagnosis of tuberculosis JOURNAL OF CLINICAL INVESTIGATION Ernst, J. D., Trevejo-Nunez, G., Banaiee, N. 2007; 117 (7): 1738-1745

Abstract

Tuberculosis kills nearly 2 million people annually, and current approaches to tuberculosis control are expensive, have limited efficacy, and are vulnerable to being overcome by extensively drug-resistant strains of Mycobacterium tuberculosis. Determination of the genome sequence of M. tuberculosis has revolutionized tuberculosis research, contributed to major advances in the understanding of the evolution and pathogenesis of M. tuberculosis, and facilitated development of new diagnostic tests with increased specificity for tuberculosis. In this review, we describe some of the major progress in tuberculosis research that has resulted from knowledge of the genome sequence and note some of the problems that remain unsolved.

View details for DOI 10.1172/JCI31810

View details for Web of Science ID 000247837700002

View details for PubMedID 17607348