Prognostic factors and risk of extrauterine metastases in 3867 women with grade 1 endometrioid corpus cancer AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY Chan, J. K., Kapp, D. S., Cheung, M. K., Shin, J. Y., Stieglitz, D., Husain, A., Teng, N. N., Berek, J. S., Osann, K., Guo, H. 2008; 198 (2)


The purpose of this study was to evaluate the role of surgical staging in patients with grade 1 endometrioid uterine cancer.Data were extracted from Surveillance, Epidemiology, and End Results Program from 1988 to 2001. Kaplan-Meier and Cox proportional hazards analyses were used to determine predictors for disease-specific survival.Twelve thousand seven hundred and twelve women were reported with endometrioid carcinoma, including 3867 with grade 1 disease, of which 25.5% had stage IC or more advanced disease, 15.4% with disease extending beyond the uterine corpus, 7.3% with extrauterine metastases, and 3.3% with lymph node metastases. On multivariate analysis, younger age and earlier stage remained as significant prognostic factors for improved survival.Since grade 1 endometrioid uterine cancers have a 15.4% risk of extrauterine spread, a complete surgical staging procedure is recommended when clinically feasible. Younger age and earlier stage are significant prognostic factors for improved survival.

View details for DOI 10.1016/j.ajog.2007.08.028

View details for Web of Science ID 000253587300026

View details for PubMedID 18226629