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Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol GENES BRAIN AND BEHAVIOR Kapfhamer, D., Bettinger, J. C., Davies, A. G., Eastman, C. L., Smail, E. A., Heberlein, U., McIntire, S. L. 2008; 7 (6): 669-676

Abstract

The mechanisms by which ethanol induces changes in behavior are not well understood. Here, we show that Caenorhabditis elegans loss-of-function mutations in the synaptic vesicle-associated RAB-3 protein and its guanosine triphosphate exchange factor AEX-3 confer resistance to the acute locomotor effects of ethanol. Similarly, mice lacking one or both copies of Rab3A are resistant to the ataxic and sedative effects of ethanol, and Rab3A haploinsufficiency increases voluntary ethanol consumption. These data suggest a conserved role of RAB-3-/RAB3A-regulated neurotransmitter release in ethanol-related behaviors.

View details for DOI 10.1111/j.1601-183X.2008.00404.x

View details for Web of Science ID 000258209600007

View details for PubMedID 18397381