Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

Learn about the flu shot, COVID-19 vaccine, and our masking policy »

Stanford Health Care

Plastic surgical delivery systems for targeted gene therapy ANNALS OF PLASTIC SURGERY Ghali, S., Dempsey, M. P., Jones, D. M., Grogan, R. H., Butler, P. E., Gurtner, G. C. 2008; 60 (3): 323-332

Abstract

The expansion of gene therapy applications from inherited disorders to acquired conditions has been mirrored by an exponential rise in both experimental work and clinical trials. This review highlights current plastic surgical delivery systems and clinical applications for targeted gene therapy. We revisit some of the vectors used both experimentally and in clinical gene therapy trials, with an emphasis on developments in plastic surgical delivery systems resulting in improved targeting of therapeutic genes. In addition, we discuss a novel technique for the delivery of gene therapy using the ex vivo transduction of free flaps, developed in our laboratory. This delivery system achieves targeted high-level transgene expression with minimal demonstrable systemic toxicity. Advances in delivery systems are essential for translating basic research into clinical therapeutics.

View details for DOI 10.1097/SAP.0b013e31806917b0

View details for Web of Science ID 000253430300017

View details for PubMedID 18443515