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Macrophage Nourishment in NASH: A Novel Role for Ketone Bodies.

Macrophage Nourishment in NASH: A Novel Role for Ketone Bodies. Hepatology (Baltimore, Md.) Torok, N. J. 2019

Abstract

Since the seminal paper by Krebs in 1966 on the regulation of hepatic ketone body production and release (1), there has been a recent resurrection of interest relating to ketogenesis and its role in tissue homeostasis. In physiological states, the liver relies on glucose for its primary fuel, while the production and export of ketone bodies provides other organs with nutrients needed to meet higher energy requirements. During increased calorie intake, hepatocytes are exposed to enhanced lipid influx, and they deal with this by increasing the tricarboxylic acid (TCA) cycle load but at the expense of enhanced redox stress. This article is protected by copyright. All rights reserved.

View details for DOI 10.1002/hep.30777

View details for PubMedID 31107977