Self-reported physical activity levels and clinical progression in early Parkinson's disease PARKINSONISM & RELATED DISORDERS Amara, A. W., Chahine, L., Seedorff, N., Caspell-Garcia, C. J., Coffey, C., Simuni, T., Marek, K., Daegelel, N., Tanner, C., Simuni, T., Coffey, C., Kieburtz, K., Wilsons, R., Mollenhauer, B., Galasko, D., Foroud, T., Chahine, L., Siderowf, A., Seibyl, J., Toga, A., Singleton, A., Weintraub, D., Trojanowski, J., Shaw, L., Tosun-Turgut, D., Poston, K., Bressman, S., Merchant, K. M., Poewe, W., Sherer, T., Chowdhury, S., Frasier, M., Kopil, C., Naito, A., Arnedo, V., Dorsey, R., Casaceli, C., Daegele, N., Albani, J., Caspell-Garcia, C., Uribe, L., Foster, E., Long, J., Seedorff, N., Crawford, K., Smiths, D., Casalin, P., Malferrari, G., Halter, C., Heathers, L., Russell, D., Factor, S., Hogarth, P., Standaert, D., Amara, A., Hauser, R., Jankovic, J., Dahodwala, N., Stern, M., Hu, S., Todd, G., Saunders-Pullman, R., Richard, I., Saint-Hilaire, M. H., Seppi, K., Shill, H., Fernandez, H., Trenkwalder, C., Oertel, W., Berg, D., Brockman, K., Wurster, I., Rosenthal, L., Tai, Y., Pavese, N., Barone, P., Isaacson, S., Espay, A., Rowe, D., Brandabur, M., Tetrud, J., Liang, G., Iranzo, A., Tolosa, E., Marder, K., Sanchez, M., Stefanis, L., Jose Marti, M., Ruiz Martinez, J., Corvol, J., Assly, J., Brillman, S., Giladi, N., Smejdir, D., Pelaggi, J., Kausar, F., Rees, L., Sommerfield, B., Freed, A., Blair, C., Williams, K., Zimmerman, G., Guthrie, S., Rawlins, A., Donhar, L., Hunter, C., Tran, B., Darin, A., Linder, C., Baca, M., Venkov, H., Thomas, C., James, R., Heim, B., Deritis, P., Sprenger, F., Raymond, D., Willeke, D., Obradov, Z., Mule, J., Monahan, N., Gauss, K., Fontaine, D., Szpak, D., Mccoy, A., Dunlop, B., Payne, L., Ainscough, S., Carvajal, L., Silverstein, R., Espay, K., Ranola, M., Mondragon Rezola, E., Mejia Santana, H., Stamelou, M., Garrido, A., Carvalho, S., Kristiansen, A., Specketer, K., Mirlman, A., Facheris, M., Soares, H., Mintun, M. A., Cedarbaum, J., Taylor, P., Jennings, D., Slieker, L., McBride, B., Watson, C., Montagut, E., Sheikh, Z., Bingol, B., Forrat, R., Sardi, P., Fischer, T., Reith, A. D., Egebjerg, J., Larsen, L., Breysse, N., Meulien, D., Saba, B., Kiyasova, V., Min, C., McAvoy, T., Umek, R., Iredale, P., Edgerton, J., De Sand, S., Czech, C., Boess, F., Sevigny, J., Kremer, T., Grachev, I., Merchant, K., Avbersek, A., Muglia, P., Stewart, A., Prashad, R., Taucher, J., Parkinsons Progression Markers 2019; 61: 118–25
Abstract
This study investigates longitudinal changes in self-reported physical activity, measured by Physical Activity Scale of the Elderly (PASE), in early Parkinson's disease (PD) and matched healthy control (HC) participants in the Parkinson's Progression Marker Initiative (PPMI) and evaluates associations between physical activity and PD progression.PPMI is a prospective, longitudinal study evaluating markers of progression in PD participants who are unmedicated at enrollment. PASE, a self-reported measure of physical activity, was administered to early PD (N?=?380) and HC (N?=?174). PASE was introduced after study launch and therefore administered at years 2, 3, and 4. PASE scores for PD and HC were compared with t-tests and changes over time were evaluated with generalized estimating equations.There were no differences in activity levels between PD and HC at any time point. However, PD participants had a longitudinal decrease in PASE from years two to four (p?=?0.034), while HC did not (p?=?0.89). In exploratory analyses controlling for age, sex, and disease duration, higher self-reported activity at year 2 were associated with slower progression of motor symptoms (p?=?0.018), ADL performance (p?
View details for DOI 10.1016/j.parkreldis.2018.11.006
View details for Web of Science ID 000468719900021
View details for PubMedID 30554993
