Autonomic impairment as a potential biomarker in idiopathic REM-sleep-behavior disorder. Autonomic neuroscience : basic & clinical Zitser, J., During, E. H., Chiaro, G., Miglis, M. G. 2019; 220: 102553


Autonomic dysfunction is common in REM-sleep behavior disorder (RBD). Several studies have demonstrated abnormalities in heart rate variability, cardiac scintigraphy, and cardiovascular autonomic reflex testing. In addition, the type and severity of these abnormalities may correlate with rate of phenoconversion from idiopathic RBD (iRBD) to manifest neurodegenerative disease. This article summarizes the current literature on autonomic impairment in iRBD, with specific focus on the role of autonomic impairment as a potential biomarker of disease progression. REM sleep physiology and relevant anatomy is also discussed in relation to the central autonomic network and autonomic neurodegeneration.

View details for DOI 10.1016/j.autneu.2019.05.005

View details for PubMedID 31219036