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HBV/HDV Coinfection: A Challenge for Therapeutics. Clinics in liver disease Koh, C., Da, B. L., Glenn, J. S. 2019; 23 (3): 557–72

Abstract

Chronic hepatitis D (CHD) results from an infection with the hepatitis B virus and hepatitis D virus (HDV). CHD is the most severe form of human viral hepatitis. Current treatment options consist of interferon alfa, which is effective only in a minority of patients. Study of HDV molecular virology has resulted in new approaches entering clinical trials, with phase-3 studies the most advanced. These include the entry inhibitor bulevirtide, the nucleic acid polymer REP 2139-Ca, the farnesyltransferase inhibitor lonafarnib, and pegylated interferon lambda. This article summarizes the available data on these emerging therapeutics.

View details for DOI 10.1016/j.cld.2019.04.005

View details for PubMedID 31266627