Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
 

Learn about the flu shot, COVID-19 vaccine, and our masking policy »

Stanford Health Care

Frequency-following response among neonates with progressive moderate hyperbilirubinemia. Journal of perinatology : official journal of the California Perinatal Association Musacchia, G., Hu, J., Bhutani, V. K., Wong, R. J., Tong, M., Han, S., Blevins, N. H., Fitzgerald, M. B. 2019

Abstract

OBJECTIVE: To evaluate the feasibility of auditory monitoring of neurophysiological status using frequency-following response (FFR) in neonates with progressive moderate hyperbilirubinemia, measured by transcutaneous (TcB) levels.STUDY DESIGN: ABR and FFR measures were compared and correlated with TcB levels across three groups. Group I was a healthy cohort (n=13). Group II (n=28) consisted of neonates with progressive, moderate hyperbilirubinemia and Group III consisted of the same neonates, post physician-ordered phototherapy.RESULT: FFR amplitudes in Group I controls (TcB=83.1±32.5mol/L; 4.9±1.9mg/dL) were greater than Group II (TcB=209.3±48.0mol/L; 12.1±2.8mg/dL). After TcB was lowered by phototherapy, FFR amplitudes in Group III were similar to controls. Lower TcB levels correlated with larger FFR amplitudes (r=-0.291, p=0.015), but not with ABR wave amplitude or latencies.CONCLUSION: The FFR is a promising measure of the dynamic neurophysiological status in neonates, and may be useful in tracking neurotoxicity in infants with hyperbilirubinemia.

View details for DOI 10.1038/s41372-019-0421-y

View details for PubMedID 31263204