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Acute Leukemias of Ambiguous Lineage: Clarification on Lineage Specificity. Surgical pathology clinics Kurzer, J. H., Weinberg, O. K. 2019; 12 (3): 687–97

Abstract

Acute leukemias of ambiguous lineage (ALAL) include acute undifferentiated leukemia and mixed-phenotype acute leukemia (MPAL). This article provides an overview of the diagnosis of ALAL and focuses on the data accounting for the current lineage-assignment criteria for blasts harboring more than one lineage-associated marker. In addition, the currently known molecular data are reviewed, which show that MPAL-associated gene mutations, methylation signatures, and expression profiles are a mixture of those seen in both acute myeloid leukemia and acute lymphoblastic leukemia. Finally, the prognosis and current treatments of MPAL are briefly discussed.

View details for DOI 10.1016/j.path.2019.03.008

View details for PubMedID 31352981