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An amine-derivatized, DOTA-loaded polymeric support for Fmoc Solid Phase Peptide Synthesis. Tetrahedron letters Yoo, B., Sheth, V. R., Pagel, M. D. 2009; 50 (31): 4459-4462

Abstract

An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.

View details for DOI 10.1016/j.tetlet.2009.05.061

View details for PubMedID 20161272

View details for PubMedCentralID PMC2702766