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Development of a Novel Canine Model for Posttraumatic Osteoarthritis of the Knee JOURNAL OF KNEE SURGERY Brimmo, O. A., Pfeiffer, F., Bozynski, C. C., Kuroki, K., Cook, C., Stoker, A., Sherman, S. L., Monibi, F., Cook, J. L. 2016; 29 (3): 235–41

Abstract

Translational models of posttraumatic osteoarthritis (PTOA) that accurately represent clinical pathology need to be developed. This study assessed a novel canine model for PTOA using impact injury. Impacts were delivered to the medial femoral condyle of dogs using a custom-designed impactor at 20, 40, or 60 MPa. Functional assessments and magnetic resonance imaging (MRI) were performed at 2 and 12 weeks, and arthroscopic and histologic assessments were performed at 12 weeks after injury. At 2 and 12 weeks, dogs had observable lameness, knee pain, effusion, loss in range of motion (ROM) and dysfunction in both hindlimbs with severity correlated strongly (r?>?0.77) to impact level. At 12 weeks, function, pain, effusion, and ROM were significantly (p?

View details for DOI 10.1055/s-0035-1549026

View details for Web of Science ID 000373292400009

View details for PubMedID 25892003