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Comparison of MRI IVIM and MR perfusion imaging in acute ischemic stroke due to large vessel occlusion. International journal of stroke : official journal of the International Stroke Society Zhu, G., Federau, C., Wintermark, M., Chen, H., Marcellus, D. G., Martin, B. W., Heit, J. J. 2019: 1747493019873515

Abstract

PURPOSE: Intravoxel incoherent motion is a diffusion-weighted imaging magnetic resonance imaging technique that measures microvascular perfusion from a multi-b value sequence. Intravoxel incoherent motion microvascular perfusion has not been directly compared to conventional dynamic susceptibility contrast perfusion-weighted imaging in the context of acute ischemic stroke. We determined the degree of correlation between perfusion-weighted imaging and intravoxel incoherent motion parameter maps in patients with acute ischemic stroke.METHODS: We performed a retrospective cohort study of acute ischemic stroke patients undergoing thrombectomy treatment triage by magnetic resonance imaging. Intravoxel incoherent motion perfusion fraction maps were derived using two-step voxel-by-voxel post-processing. Ischemic core, penumbra, non-ischemia, and contralateral hemisphere were delineated based upon diffusion-weighted imaging and perfusion-weighted imaging using a Tmax >6s threshold. Signal intensity within different brain compartments were measured on intravoxel incoherent motion (IVIM f, IVIM D*, IVIM fD*) parametric maps and compared the differences using one-way ANOVA. Ischemic volumes were measured on perfusion-weighted imaging and intravoxel incoherent motion parametric maps. Bland-Altman analysis and voxel-based volumetric comparison were used to determine the agreements among ischemic volumes of perfusion-weighted imaging and intravoxel incoherent motion perfusion parameters. Inter-rater reliability on intravoxel incoherent motion maps was also assessed. Significance level was set at alpha<0.05.RESULTS: Twenty patients (11 males, 55%; mean age 67.1±13.8 years) were included. Vessel occlusions involved the internal carotid artery (6 patients, 30%) and M1 segment of the middle cerebral artery (14, 70%). Mean pre-treatment core infarct volume was 19.07±23.56ml. Mean pre-treatment ischemic volumes on perfusion-weighted imaging were 10.90±13.33ml (CBV), 24.83±23.08ml (CBF), 58.87±37.85ml (MTT), and 47.53±26.78ml (Tmax). Mean pre-treatment ischemic volumes on corresponding IVIM parameters were 23.20±25.63ml (IVIM f), 14.01±16.81ml (IVIM D*), and 27.41±40.01ml (IVIM fD*). IVIM f, D, and fD* demonstrated significant differences (P<0.001). The best agreement in term of ischemic volumes and voxel-based overlap was between IVIM fD* and CBF with mean volume difference of 0.5ml and mean dice similarity coefficient (DSC) of 0.630±0.136.CONCLUSION: There are moderate differences in brain perfusion assessment between intravoxel incoherent motion and perfusion-weighted imaging parametric maps, and IVIM fD* and perfusion-weighted imaging CBF show excellent agreement. Intravoxel incoherent motion is promising for cerebral perfusion assessment in acute ischemic stroke patients.

View details for DOI 10.1177/1747493019873515

View details for PubMedID 31480940