Conditional disease-free survival after curative-intent liver resection for neuroendocrine liver metastasis. Journal of surgical oncology Sahara, K. n., Merath, K. n., Tsilimigras, D. I., Hyer, J. M., Guglielmi, A. n., Aldrighetti, L. n., Weiss, M. n., Fields, R. C., Poultsides, G. A., Maithel, S. K., Endo, I. n., Pawlik, T. M., Other Members Of The U S Neuroendocrine Tumor Study Group, n. n. 2019


Neuroendocrine liver metastases (NELM) are typically associated with high recurrence rates following surgical resection. Conditional disease-free survival (CDFS) estimates may be more clinically relevant compared to actuarial survival estimates.CDFS was assessed using a multi-institutional cohort of patients. Cox proportional hazards models were used to evaluate factors associated with disease-free survival (DFS). Three-year CDFS (CDFS3) estimates at "x" year after surgery were calculated as CDFS3 ?=?DFS(x?+?3)/DFS(x).A total of 521 patients met the inclusion criteria. While actuarial 3-year DFS gradually decreased from 49% at 1 year to 39% at 5 years, CDFS3 increased over time. CDFS3 at 5 years was estimated as 89% vs actuarial 8-year DFS of 39% (P?

View details for DOI 10.1002/jso.25713

View details for PubMedID 31550406