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Lymphovascular Invasion Is Associated with Lymph Node Involvement in Small Appendiceal Neuroendocrine Tumors. Annals of surgical oncology Blakely, A. M., Raoof, M. n., Ituarte, P. H., Fong, Y. n., Singh, G. n., Lee, B. n. 2019; 26 (12): 4008–15

Abstract

Appendiceal neuroendocrine tumors (NETs) are incidentally found in up to 1% of appendectomy specimens. The association of lymphovascular invasion (LVI) with risk of regional lymph node involvement is unclear.From the National Cancer Database, 2004-2015, this study identified patients who had tumors 2 cm or smaller with one or more lymph nodes (LNs) pathologically evaluated. The histology was defined as typical, goblet cell, or composite NETs. Patient demographics, tumor characteristics, and treatment variables were analyzed.The histologies for the 1767 identified patients were typical (n?=?921, 52.1%), goblet cell (n?=?556, 31.5%), and composite (n?=?290, 16.4%). The tumor grades were low (70.4%), moderate (18.6%), and high (11%). The overall LN positivity was 17%. Of 1052 tumors evaluated, 215 (20.4%) had LVI. Overall survival decreased with node involvement (mean 84 vs. 124 months; p?

View details for DOI 10.1245/s10434-019-07637-9

View details for PubMedID 31359272