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LYMPHOCYTE-T-SYNOVIAL FIBROBLAST INTERACTIONS INDUCED BY MYCOBACTERIAL PROTEINS IN RHEUMATOID-ARTHRITIS ARTHRITIS AND RHEUMATISM Holoshitz, J., Kosek, J., Sibley, R., Brown, D. A., Strober, S. 1991; 34 (6): 679-686

Abstract

An in vitro system was established in which single-cell suspensions of lymphocytes and synovial cells from the joints of patients with rheumatoid arthritis were cultured and produced an outgrowth of an organized inflammatory tissue with an extracellular matrix and capsule. The tissue outgrowth, which had histologic features of pannus, required the addition of mycobacterial antigen and interleukin-2 to the tissue culture medium and was dependent upon the presence of T lymphocytes and their interaction with synovial fibroblasts.

View details for Web of Science ID A1991FR47300006

View details for PubMedID 1905130