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Preoperative systemic inflammatory markers are prognostic indicators in recurrent adrenocortical carcinoma.

Preoperative systemic inflammatory markers are prognostic indicators in recurrent adrenocortical carcinoma. Journal of surgical oncology Gaitanidis, A. n., Wiseman, D. n., El Lakis, M. n., Nilubol, N. n., Kebebew, E. n., Patel, D. n. 2019

Abstract

Recurrent adrenocortical carcinoma (ACC) has a poor prognosis with minimal clinical and biochemical factors to guide management. The aim of this study was to evaluate the prognostic significance of systemic inflammatory response in patients with recurrent ACC.Patients who underwent resection for recurrent ACC were retrospectively analyzed. Preoperative neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio (LMR), and mean platelet volume were calculated.Twenty-five patients (age at operation 52.2?±?9.5 years) were identified. We observed a statistically significant shorter disease-specific survival (DSS) in patients with LMR less than 4 (41?±?7.4 months vs 71 ± 12.3, P?=?.023) and male sex (26.6?±?4.2 months vs 57.6?±?9.5 months, P?=?.079), while time-to-recurrence (TTR) less than 12 months (40?±?7.7 months vs 70.3?±?13.1 months, P?=?.059) had a trend on univariate analysis for worse DSS. On multivariable analysis, LMR

View details for DOI 10.1002/jso.25760

View details for PubMedID 31733070