To define early versus late recurrence based on post-recurrence survival (PRS) among patients undergoing curative resection for hepatocellular carcinoma (HCC).Patients who underwent curative-intent resection for HCC between 2000 and 2017 were identified from an international multi-institutional database. The optimal cut-off time point to discriminate early versus late recurrence was determined relative to PRS.Among 1004 patients, 443 (44.1%) patients experienced recurrence with a median recurrence-free survival time of 12 months. A cut-off time point of 8 months was defined as the optimal threshold based on sensitivity analyses relative to PRS for early (n?=?165, 37.2%) versus late relapse (n?=?278, 62.8%) (p?=?0.008). Early recurrence was associated with worse PRS (median PRS, 27.0 vs. 43.0 months, p?=?0.019), as well as overall survival (OS) (median OS, 32.0 versus 74.0 months, p?
View details for DOI 10.1007/s11605-020-04553-2
View details for PubMedID 32128681