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Early Versus Late Recurrence of Hepatocellular Carcinoma After Surgical Resection Based on Post-recurrence Survival: an International Multi-institutional Analysis. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract Wei, T. n., Zhang, X. F., Bagante, F. n., Ratti, F. n., Marques, H. P., Silva, S. n., Soubrane, O. n., Lam, V. n., Poultsides, G. A., Popescu, I. n., Grigorie, R. n., Alexandrescu, S. n., Martel, G. n., Workneh, A. n., Guglielmi, A. n., Hugh, T. n., Lv, Y. n., Aldrighetti, L. n., Pawlik, T. M. 2020

Abstract

To define early versus late recurrence based on post-recurrence survival (PRS) among patients undergoing curative resection for hepatocellular carcinoma (HCC).Patients who underwent curative-intent resection for HCC between 2000 and 2017 were identified from an international multi-institutional database. The optimal cut-off time point to discriminate early versus late recurrence was determined relative to PRS.Among 1004 patients, 443 (44.1%) patients experienced recurrence with a median recurrence-free survival time of 12 months. A cut-off time point of 8 months was defined as the optimal threshold based on sensitivity analyses relative to PRS for early (n?=?165, 37.2%) versus late relapse (n?=?278, 62.8%) (p?=?0.008). Early recurrence was associated with worse PRS (median PRS, 27.0 vs. 43.0 months, p?=?0.019), as well as overall survival (OS) (median OS, 32.0 versus 74.0 months, p?

View details for DOI 10.1007/s11605-020-04553-2

View details for PubMedID 32128681