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Targeting Vascular Calcification in Chronic Kidney Disease.
Targeting Vascular Calcification in Chronic Kidney Disease. JACC. Basic to translational science Nelson, A. J., Raggi, P., Wolf, M., Gold, A. M., Chertow, G. M., Roe, M. T. 2020; 5 (4): 398–412Abstract
Cardiovascular (CV) disease remains an important cause of morbidity and mortality for patients with chronic kidney disease (CKD). Although clustering of traditional risk factors with CKD is well recognized, kidney-specific mechanisms are believed to drive the disproportionate burden of CV disease. One perturbation that is frequently observed at high rates in patients with CKD is vascular calcification, which may be a central mediator for an array of CV sequelae. This review summarizes the pathophysiological bases of intimal and medial vascular calcification in CKD, current strategies for diagnosis and management, and posits vascular calcification as a risk marker and therapeutic target.
View details for DOI 10.1016/j.jacbts.2020.02.002
View details for PubMedID 32368697