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The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19? Cell host & microbe McKechnie, J. L., Blish, C. A. 2020

Abstract

The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics.

View details for DOI 10.1016/j.chom.2020.05.009

View details for PubMedID 32464098