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Very Early Recurrence After Liver Resection for Intrahepatic Cholangiocarcinoma: Considering Alternative Treatment Approaches. JAMA surgery Tsilimigras, D. I., Sahara, K. n., Wu, L. n., Moris, D. n., Bagante, F. n., Guglielmi, A. n., Aldrighetti, L. n., Weiss, M. n., Bauer, T. W., Alexandrescu, S. n., Poultsides, G. A., Maithel, S. K., Marques, H. P., Martel, G. n., Pulitano, C. n., Shen, F. n., Soubrane, O. n., Koerkamp, B. G., Moro, A. n., Sasaki, K. n., Aucejo, F. n., Zhang, X. F., Matsuyama, R. n., Endo, I. n., Pawlik, T. M. 2020

Abstract

Although surgery offers the best chance of a potential cure for patients with localized, resectable intrahepatic cholangiocarcinoma (ICC), prognosis of patients remains dismal largely because of a high incidence of recurrence.To predict very early recurrence (VER) (ie, recurrence within 6 months after surgery) following resection for ICC in the pre- and postoperative setting.Patients who underwent curative-intent resection for ICC between May 1990 and July 2016 were identified from an international multi-institutional database. The study was conducted at The Ohio State University in collaboration with all other participating institutions. The data were analyzed in December 2019.Two logistic regression models were constructed to predict VER based on pre- and postoperative variables. The final models were used to develop an online calculator to predict VER and the tool was internally and externally validated.Among 880 patients (median age, 59 years [interquartile range, 51-68 years]; 388 women [44.1%]; 428 [50.2%] white; 377 [44.3%] Asian; 27 [3.2%] black]), 196 (22.3%) developed VER. The 5-year overall survival among patients with and without VER was 8.9% vs 49.8%, respectively (P?

View details for DOI 10.1001/jamasurg.2020.1973

View details for PubMedID 32639548