Circulating preoperative testosterone level predicts unfavourable disease at radical prostatectomy in men with International Society of Urological Pathology Grade Group 1 prostate cancer diagnosed with systematic biopsies. World journal of urology Ferro, M. n., Lucarelli, G. n., de Cobelli, O. n., Vartolomei, M. D., Damiano, R. n., Cantiello, F. n., Crocerossa, F. n., Perdonà, S. n., Del Prete, P. n., Cordima, G. n., Musi, G. n., Del Giudice, F. n., Busetto, G. M., Chung, B. I., Porreca, A. n., Ditonno, P. n., Battaglia, M. n., Terracciano, D. n. 2020


The association between circulating total testosterone (T) levels and clinically significant PCa is still a matter of debate. In this study, we evaluated whether serum testosterone levels may have a role in predicting unfavorable disease (UD) and biochemical recurrence (BCR) in patients with clinically localized (=?cT2c) ISUP grade group 1 PCa at biopsy.408 patients with ISUP grade group 1 prostate cancer, undergone to radical prostatectomy and T measurement were included. The outcome of interest was the presence of unfavourable disease (UD) defined as ISUP grade group [Formula: see text] 3 and/or pT [Formula: see text] 3a.Statistically significant differences resulted between serum testosterone values and ISUP grade groups (P?

View details for DOI 10.1007/s00345-020-03368-9

View details for PubMedID 32683462