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Cerebrospinal Fluid Metals and the Association with Cerebral Small Vessel Disease. Journal of Alzheimer's disease : JAD Shams, M. n., Martola, J. n., Charidimou, A. n., Granberg, T. n., Ferreira, D. n., Westman, E. n., Wintermark, M. n., Iv, M. n., Larvie, M. n., Kristoffersen Wiberg, M. n., Kaijser, M. n., Forsgard, N. n., Zetterberg, H. n., Wahlund, L. O., Shams, S. n. 2020

Abstract

Brain metal homeostasis is essential for brain health, and deregulation can result in oxidative stress on the brain parenchyma.Our objective in this study was to focus on two hemorrhagic MRI manifestations of small vessel disease [cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS)] and associations with cerebrospinal fluid (CSF) iron levels. In addition, we aimed to analyze CSF biomarkers for dementia and associations with CSF metal levels.This is a cross-sectional study of 196 patients who underwent memory clinic investigation, including brain MRI. CSF was collected and analyzed for metals, amyloid-ß (Aß) 42, total tau (T-tau), and phosphorylated tau (P-tau), and CSF/serum albumin ratios. Statistical analyses were performed using generalized linear models.No significant difference was found between CSF metal levels across diagnostic groups. Higher iron and copper levels were associated with higher CSF levels of Aß42, T-tau, P-tau, and CSF/serum albumin ratios (p?

View details for DOI 10.3233/JAD-200656

View details for PubMedID 33104030