A Patient with HIV Treated with Ipilimumab and Stereotactic Radiosurgery for Melanoma Metastases to the Brain CASE REPORTS IN ONCOLOGICAL MEDICINE Ruzevick, J., Nicholas, S., Redmond, K., Kleinberg, L., Lipson, E. J., Lim, M. 2013: 946392


Cancers, such as melanoma, that are associated with immune deficiencies are a major cause of morbidity and mortality in HIV-infected patients. Once patients develop melanoma metastases to the brain, treatment is often limited to palliative surgery and/or radiation. Ipilimumab, a CTLA-4 antagonist, has been shown to improve the median survival of patients with metastatic melanoma. However, available data regarding the safety and efficacy of ipilimumab in HIV-infected patients who develop intracranial melanoma metastases is limited. Here we report our experience administering ipilimumab to a patient with HIV-AIDS who developed multiple intracranial melanoma metastases. Following treatment, our patient showed improvement in systemic tumor control without any apparent interference with antiretroviral treatment.

View details for DOI 10.1155/2013/946392

View details for Web of Science ID 000215599700103

View details for PubMedID 24383025

View details for PubMedCentralID PMC3870634