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The Neuroimmunology of Chronic Pain: From Rodents to Humans.

The Neuroimmunology of Chronic Pain: From Rodents to Humans. The Journal of neuroscience : the official journal of the Society for Neuroscience Grace, P. M., Tawfik, V. L., Svensson, C. I., Burton, M. D., Loggia, M. L., Hutchinson, M. R. 2020

Abstract

Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chronic pain. This review highlights recent advances in understanding fundamental neuroimmune signaling mechanisms and novel therapeutic targets in rodent models of chronic pain. We further discuss new technological developments to study, diagnose, and quantify neuroimmune contributions to chronic pain in patient populations.

View details for DOI 10.1523/JNEUROSCI.1650-20.2020

View details for PubMedID 33239404