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The Clinical Utility of 18F-Fluciclovine PET/CT in Biochemically Recurrent Prostate Cancer: an Academic Center Experience Post FDA Approval. Molecular imaging and biology Nakamoto, R. n., Harrison, C. n., Song, H. n., Guja, K. E., Hatami, N. n., Nguyen, J. n., Moradi, F. n., Franc, B. L., Aparici, C. M., Davidzon, G. n., Iagaru, A. n. 2021

Abstract

To evaluate the diagnostic performance and clinical utility of 18F-fluciclovine PET/CT in patients with biochemical recurrence (BCR) of prostate cancer (PC).18F-Fluciclovine scans of 165 consecutive men with BCR after primary definitive treatment with prostatectomy (n?=?102) or radiotherapy (n?=?63) were retrospectively evaluated. Seventy patients had concurrent imaging with at least one other conventional modality (CT (n?=?31), MRI (n?=?31), or bone scan (n?=?26)). Findings from 18F-fluciclovine PET were compared with those from conventional imaging modalities. The positivity rate and impact of 18F-fluciclovine PET on patient management were recorded. In 33 patients who underwent at least one other PET imaging (18F-NaF PET/CT (n?=?12), 68Ga-PSMA11 PET/CT (n?=?5), 18F-DCFPyL PET/CT (n?=?20), and 68Ga-RM2 PET/MRI (n?=?5)), additional findings were evaluated.The overall positivity rate of 18F-fluciclovine PET was 67 %, which, as expected, increased with higher prostate-specific antigen (PSA) levels (ng/ml): 15 % (PSA?

View details for DOI 10.1007/s11307-021-01583-3

View details for PubMedID 33469884