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Type 1 diabetic Akita mice have low bone mass and impaired fracture healing. Bone Hu, P. n., McKenzie, J. A., Buettmann, E. G., Migotsky, N. n., Gardner, M. J., Silva, M. J. 2021: 115906

Abstract

Type 1 diabetes (T1DM) impairs bone formation and fracture healing in humans. Akita mice carry a mutation in one allele of the insulin-2 (Ins2) gene, which leads to pancreatic beta cell dysfunction and hyperglycemia by 5-6?weeks age. We hypothesized that T1DM in Akita mice is associated with decreased bone mass, weaker bones, and impaired fracture healing. Ins2 +/- (Akita) and wildtype (WT) males were subjected to femur fracture at 18-weeks age and healing assessed 3-21?days post-fracture. Non-fractured left femurs were assessed for morphology (microCT) and strength (bending or torsion) at 19-21?weeks age. Fractured right femurs were assessed for callus mechanics (torsion), morphology and composition (microCT and histology) and gene expression (qPCR). Both Akita and WT mice gained weight from 3 to 18?weeks age, but Akita mice weighed less starting at 5?weeks (-5.2%, p?

View details for DOI 10.1016/j.bone.2021.115906

View details for PubMedID 33662611