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Predictors of Time-in-Range (70-180?mg/dL) Achieved Using a Closed-Loop Control System. Diabetes technology & therapeutics Schoelwer, M. J., Kanapka, L. G., Wadwa, R. P., Breton, M. D., Ruedy, K. J., Ekhlaspour, L. n., Forlenza, G. P., Cobry, E. C., Messer, L. H., Cengiz, E. n., Jost, E. n., Carria, L. n., Emory, E. n., Hsu, L. J., Weinzimer, S. A., Buckingham, B. A., Lal, R. A., Oliveri, M. C., Kollman, C. C., Dokken, B. B., Cherñavvsky, D. R., Beck, R. W., DeBoer, M. D. 2021

Abstract

Background: Studies of closed-loop control (CLC) in patients with type 1 diabetes (T1D) consistently demonstrate improvements in glycemic control as measured by increased time-in-range (TIR) 70-180?mg/dL. However, clinical predictors of TIR in users of CLC systems are needed. Materials and Methods: We analyzed data from 100 children aged 6-13 years with T1D using the Tandem Control-IQ CLC system during a randomized trial or subsequent extension phase. Continuous glucose monitor data were collected at baseline and during 12-16 weeks of CLC use. Participants were stratified into quartiles of TIR on CLC to compare clinical characteristics. Results: TIR for those in the first, second, third, and fourth quartiles was 54%, 65%, 71%, and 78%, respectively. Lower baseline TIR was associated with lower TIR on CLC (r?=?0.69, P?

View details for DOI 10.1089/dia.2020.0646

View details for PubMedID 33689454