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COVID-19 vaccination in mastocytosis: recommendations of the European Competence Network on Mastocytosis (ECNM) and American Initiative in Mast Cell Diseases (AIM). The journal of allergy and clinical immunology. In practice Bonadonna, P. n., Brockow, K. n., Niedoszytko, M. n., Elberink, H. O., Akin, C. n., Nedoszytko, B. n., Butterfield, J. H., Alvarez-Twose, I. n., Sotlar, K. n., Schwaab, J. n., Jawhar, M. n., Castells, M. n., Sperr, W. R., Hermine, O. n., Gotlib, J. n., Zanotti, R. n., Reiter, A. n., Broesby-Olsen, S. n., Bindslev-Jensen, C. n., Schwartz, L. B., Horny, H. P., Radia, D. n., Triggiani, M. n., Sabato, V. n., Carter, M. C., Siebenhaar, F. n., Orfao, A. n., Grattan, C. n., Metcalfe, D. D., Arock, M. n., Gulen, T. n., Hartmann, K. n., Valent, P. n. 2021

Abstract

Mastocytosis is a neoplasm characterized by an accumulation of mast cells in various organs and increased risk for severe anaphylaxis in patients with concomitant allergies. Covid-19 is a pandemic that is associated with a relatively high rate of severe lung disease and mortality. The mortality is particularly high in those with certain comorbidities and increases with age. Recently, several companies have developed an effective vaccination against Covid-19. Although the reported frequency of severe side effects is low, there is an emerging discussion about the safety of Covid-19 vaccination in patients with severe allergies and mastocytosis. However, even in these patients, severe adverse reactions are rare. We therefore recommend the broad use of Covid-19 vaccination in patients with mastocytosis on a global basis. The only well-established exception is a known or suspected allergy against a constituent of the vaccine. Safety measures, including premedication and post-vaccination observation should be considered in all patients with mastocytosis, depending on the individual personal risk and overall situation in each case. The current article provides a summary of published data, observations and expert opinion that form the basis of these recommendations.

View details for DOI 10.1016/j.jaip.2021.03.041

View details for PubMedID 33831618