Relationship between apparent diffusion coefficient and subsequent hemorrhagic transformation following acute ischemic stroke STROKE Tong, D. C., Adami, A., Moseley, M. E., Marks, M. P. 2000; 31 (10): 2378-2384


A method for identifying patients at increased risk for developing secondary hemorrhagic transformation (HT) after acute ischemic stroke could be of significant value, particularly in patients being considered for thrombolytic therapy. We hypothesized that diffusion-weighted MRI might aid in the identification of such patients.We retrospectively analyzed 17 patients with ischemic stroke who received diffusion-weighted MRI within 8 hours of symptom onset and who also received follow-up neuroimaging within 1 week of initial scan. The apparent diffusion coefficient (ADC) for each pixel in the whole ischemic area was calculated, generating a histogram of values. Areas subsequently experiencing HT were then compared with areas not experiencing HT to determine the relationship between ADC and subsequent HT.A significantly greater percentage of pixels possessed lower ADCs ( 40% of the pixels possessed values

View details for Web of Science ID 000089655900016

View details for PubMedID 11022067