The Role of Surgical Lung Biopsy in the Diagnosis of Fibrotic Interstitial Lung Disease: Perspective from the Pulmonary Fibrosis Foundation. Annals of the American Thoracic Society Hariri, L. P., Roden, A. C., Chung, J. H., Danoff, S. K., Gomez Manjarres, D. C., Hartwig, M., Kheir, F., King, C., Kreider, M., Lynch, D. A., Mooney, J., Muniappan, A., Myers, J. L., Paoletti, L., Raj, R., Safdar, Z., Suliman, S., Thavarajah, K., Lederer, D. J., Rudell, F. L., Bianchi, P., Shea, B. S., Ley, B. 2021


Diagnosis of interstitial lung disease (ILD) requires a multidisciplinary diagnosis (MDD) approach that includes clinicians, radiologists, and pathologists. Surgical lung biopsy (SLB) is currently the recommended standard in obtaining pathological specimens for patients with ILD requiring a tissue diagnosis. The increased diagnostic confidence and accuracy provided by microscopic pathology assessment of SLB specimens must be balanced with the associated risks in ILD patients. This document was developed by the Surgical Lung Biopsy Working Group of the Pulmonary Fibrosis Foundation, composed of a multidisciplinary group of ILD physicians including pulmonologists, radiologists, pathologists, and thoracic surgeons. In this document, we present an up-to-date literature review of the indications, contraindications, risks, and alternatives to SLB in the diagnosis of fibrotic ILD, outline an integrated approach to the decision-making around SLB in the diagnosis of fibrotic ILD, and provide practical information to maximize the yield and safety of SLB.

View details for DOI 10.1513/AnnalsATS.202009-1179FR

View details for PubMedID 34004127